H1N1 D225G and D225N in Moldova Patient



	Home	Founder	What's New	In The News	Consulting



H1N1 Consulting Paradigm Shift Viral Evolution Intervention Monitoring Vaccine Screening Vaccine Development Expression Profiling Drug Discovery Custom Therapies Patents	Audio:Nov 24 Dec2 Dec17 Dec30 twitter Live feed of underlying pandemic map data here Commentary H1N1 D225G in Nasopharyngeal Swab from Fatal Brazil Case Recombinomics Commentary 16:57 January 10, 2010 Recently released HA sequences from Ukraine and Moldova have had D225G and D225N in the same patients, which appear to be isolated from fatal cases (the Moldova sample was collected when the first fatal case in Moldova died). Moreover, the case fatality rate (CFR) for patients in D225G, D225N, or both in Ukraine, Russia, and Moldova has been at 100%. However, most of the samples with these changes were from the infected tissues in the throat or lungs, while most samples tested are nasopharyngeal swabs, raising concerns that the high frequency of the RBD changes is linked to sample collection. Samples from mild cases are typically nasopharyngeal swabs, which may have low levels of virus with the RBD changes. Brazil is another country with a 100% CFR. However, all four of the prior cases involved lung or trachea samples. However, the Respiratory Viruses and Measles Laboratory in Brazil has recently released five HA sequences from fatal cases including one, A/Rio de Janeiro/5826/2009, which was from a "nasopharyngeal secretion" collected on Jul 28 (32M), demonstrating that detection of D225G in fatal cases was not limited to the infected tissue sources. This new sample keeps the Brazil CFR at 100%, but raises the number of samples with D225G or D225N to five. Ukraine still has the highest number of reported cases, at 8, but as a group the number of public sequences with D225G, D225N or both is growing rapidly, increasing the association with fatal or severe cases. The increasing frequency of these changes continues to raise concerns that the emergence of such changes could create a catastrophic new wave. D225G in Ukraine has already produced a "low reactor" result, and D225G in swine is common. Currently, detection of D225G/N is rare, but the increasing frequency raises concerns. Media Links Recombinomics Presentations Recombinomics Publications Recombinomics Paper at Nature Precedings

Home | Founder | What's New | In The News | Contact Us