Fatal H1N1 Cluster in Romania Raises Concerns



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H1N1 Consulting Paradigm Shift Viral Evolution Intervention Monitoring Vaccine Screening Vaccine Development Expression Profiling Drug Discovery Custom Therapies Patents	Audio:Nov 24 Dec2 Dec17 Dec30 twitter Live feed of underlying pandemic map data here Commentary Fatal H1N1 Cluster in Romania Raises Concerns Recombinomics Commentary 19:42 January 12, 2010 This is a woman of 42 years of Caracal, mother of a young friend of 21 years died a few days ago, confirmed also A/H1N1 virus. The two did not become ill from one another but had a common source from which they contracted the virus, "said Madan Marinela The above translation describes two fatal H1N1 infections in Caracal, Romania which were said to have come from a common source. Although fatalities in eastern Europe have been rising, the case fatality rate has been well below 0.1%. Therefore the deaths of two patients from a common source would be cause for concern. Recently released sequences from the region have had receptor binding domain change at position 225. Two such changes, D225G and D225N have been linked to a case fatality rate of 100% in many of the countries in the region. Since detection of these two polymorphisms is low, the overall H1N1 is also low, but there are concerns that an increase in frequency in such sequences would lead to clear transmission and a dramatic jump in CFR. The first indication of such changes would be clusters of cases such was the two described above. More information on these two cases and the common source would be useful. Media Links Recombinomics Presentations Recombinomics Publications Recombinomics Paper at Nature Precedings

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