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December H1N1 UK Sequences Have S188T
Recombinomics
Commentary 23:50
January 18, 2011
The recently released sequences from Iran from mid-December focused attention on the emergence of H1N1 with either S186P or S188T. All four had one of the two changes and three had S188T.
A closer look at the recently released sequences from the UK showed a similar trend.
Ten of the UK sequences were collected in December, and all ten had S188T. All ten had G605C (S188T), T1056C, G1403A (S454N), as had been previously described for the clonal expansion of S188T. However, in the UK the December isolates formed two branches.
The branch which acquired G340A (D100N) via recombination had the two severe cases with D225G (A/England/488038/2010 and A/England/4940476/2010), and a fatal case (A/England/5040499/2010). The other branch had A40G, G207A, and G1629T, which had seven milder cases (A/England/280/2010, A/England/5000135/2010, A/England/5000125/2010, A/England/4980078/2010, A/England/4980074/2010, A/England/4960201/2010, and A/England/4940126/2010).
A similar trend was seen in the November collections. Ten more had S188T, while six had S186P. Only one of the seventeen November collections did not have one of the receptor binding domain change.
These data highlight the emergence of sequences with either S186P or S188T, as well as S188T increasing in frequency in the most recent collections.
A similar trend was seen in the United States and Japan, signaling the emergence and fixing of these changes in 2011.
Release of December H1N1 sequences from additional countries would be useful.
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