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Commentary
Hunan H7N9 Cluster In Jiangyong - 38M & 8F
Recombinomics Commentary 16:00
February 3, 2014
The case is currently under treatment in a hospital in Yongzhou. Close contacts of the cases have been timely measures taken under medical observation, as of now were not unusual.
Case Yang Moumou, female, 8 years old, student, who lives in Jiangyong County, Yongzhou City, Hunan Province, have live bird markets exposure history. Now stable condition in Yongzhou a hospital.
The above translations media reports describing two recent H7N9 bird flu cases (38M & 8F) in Hunan Province in Jiangyong County, Yongzhou City. These two cases were reported one day apart and the confirmation of a child with mild or stable H7N9 that is geographically and temporally linked to a severe or fatal adult case raises concerns that these young cases are contacts of the severe cases.
China has focused surveillance on severe hospitalized cases, but recently has cited milder cases, with these linkages in time and space. Sequences from these clusters have been largely lacking, but these associations are far from random.
The above cluster in Hunan Province is within 100 miles of a similar cluster in Guandong Province (28M and 5M) and each cluster is less than 50 miles from the first H7N9 case (56F) in Guangxi province (see map).
Moreover, an additional Guangdong cluster was created today by the report of a 2 ½ year old female (2M) in Sanjiaoshen, which followed a report of a critical case (37M) from the same location (see map) reported a day earlier.
These cases and clusters raise concerns that the efficiency of human to human (H2H) H7N9 transmission is increasing.
Release of sequences from these clusters, as well as the relationships between the cluster members, would be useful.
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