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Audio: Apr21 Sep22
Nov10 Jan19  
Commentary
H1N1
Oseltamivir Resistance in Taiwan During 2008-2009
Recombinomics Commentary
08:44
February 5, 2009
In the past 3 weeks (January 11-31 2009), influenza activity increased
rapidly in Taiwan. Currently, the influenza A/H1N1 viruses have
become the predominant subtype, and H3N2 viruses also co-circulated.
During 2007-2008 flu season, influenza A/H1N1 viruses predominantly
circulated in Taiwan and the viruses were all sensitive to
Oseltamivir. However, starting from September to December in
2008, an average of 46% resistance (22/48), with the H274Y mutation in
the NA, was detected by Taiwan Centers for Disease Control (Taiwan
CDC). The more detailed month-to-month proportion figures of
resistant viruses are as follows: 0% (0/21) from January to August,
11.1 % (2/18) in September, 27.3 % (3/11) in October, 66.7 % (2/3) in
November, and 100% (15/15) in December. It seems that there was a fast
increasing trend of Oseltamivir resistance in Taiwan from September
2008.
Ho-Sheng Wu, Ph.D.
Director, Research and Diagnostic Center
Director, National Influenza Center
Centers for Disease Control, Taiwan
Recombinomics thanks Dr Wu for
the first hand knowledge on the evolving influenza situation in Taiwan.
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