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Commentary
Adamantane Sensitive
H1N1 in Houston Texas
Recombinomics
Commentary 18:08
February 15, 2010
The above comments from the latest CDC influenza update refers to a table which has 1188/1191 H1N1 isolates with adamantane resistance (S31N in M2). Recently released sequences by JCVI included two adamantane sensitive sequences from the Houston, TX area. The two samples (A/Texas/45103259/2009 and A/Texas/45062633/2009) were collected four days apart in September, suggesting the isolates were from contacts or from the same patient (age and gender were not included). These changes signal an increase in H1N1 evolution which is driven by the immunological response to the spread of H1N1 worldwide and in Texas.
The MP sequence is closely related to other swine H1N1 sequences, indicating the sensitivity was not due to reassortment involving a human MP gene segment or an adamantane sensitive swine sequence. Several additional polymorphisms in MP and throughout the two flu genomes were found in a series of isolates from Texas, indicating the S31 was a recent acquisition.
The increase in H1N1 evolution raises concerns that variants such as those with D225G and D225N will become dominant in the next wave, which may have already started in region 4 as well as Mexico.
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