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Commentary
Another H5N1
Bali Indonesia Fatality
Recombinomics Commentary 16:00
February 21, 2012
"Based on the PCR, he's positive, "he said. case of death of this child is the fifth death from bird flu virus that occurred in Bali.
The above translation describes lab confirmation of another fatal H5N1 case (12M) in Bali. Earlier, sequences from a Bali cluster of three were released. The sequence from the mother was a recombined sequence derived from the sequences from her children. The sequences had multiple receptor binding domain changes, which may have been present in the Indonesian clade 2.1 H5N1 used in the Ron Fouchier transmission experiments, which began with three changes and acquired two additional changes. The five changes in two genes represented previously reported polymorphisms, which were used in ferret transmission experiments. The death of all 40 exposed ferrets has raised concerns that a lethal transmitting H5N1 could emerge in the near term.
The recent clusters in Indonesia and Egypt have raised concerns that the withholding of the details in the Fouchier and Kawaoka experiments continues to be hazardous to the world’s health.
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