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Commentary
H1N1 H274Y Tamiflu
Resistance in Italian Recombinant
Recombinomics
Commentary 18:29
February 28, 2010
The release of this sequence follows the release of 13 recent sequences from Japan. 10 had H274Y, including a January, 2010 collection. The increased detection of H274Y in the limited number of 2010 sequences raises concerns that Tamiflu resistance, like D225G/N, is on the rise.
These markers move around via recombination, which allows for jumping from one genetic background to another. In the Italian NA sequence there fist polymorphism matched the two polymorphisms in China, which provide another example of recombination. These examples are difficult to explain by the “random mutation” paradigm of WHO and collaborators. The H274Y in the above isolate is on yet another genetic background, adding further support for recombination. D225G/N has also been found on multiple genetic backgrounds, in addition to concentration in one sub-clade found largely, in Ukraine and Russia.
These increasing frequencies of H274Y and D225G/N raise concerns that as a new wave develops, new variants will arise with D225G/N and H274Y.
The increasing reports of H274Y in 2010 isolates add to those concerns.
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