Uvs Lake Czech Republic H5N1 Has G743A
Recombinomics Commentary 21:14
March 3, 2008
Full sequences from H5N1 outbreaks in the Czech Republic over the summer of 2007 were released at Genbank. The first isolate (A/turkey/Czech Republic/10309-3/07), was collected on June 19 from a poultry outbreak. The second isolate, A/Cygnus olor/Czech Republic/10732/07 was from a mute swan in Lednice collected on June 25. The third isolate, A/chicken/Czech Republic/11242-38/07, was from a July poultry outbreak.
As reported, all three isolates were clade 2.2.3 that link back to the Uvs Lake outbreak in the summer of 2006 in Mongolia. The outbreak in the Czech Republic was the first reported outbreak in the summer. The poultry outbreak was quickly followed by the wild bird in Lednice, as well as multiple wild bird outbreaks in Germany. These outbreaks were followed by wild bird outbreaks in France.
The swan sequence is most closely related to the three sequences from the outbreak in Romania. The two poultry outbreaks form a separate branch, but are most closely related to the Czech Republic and Romanian isolates.
The sequences are also related to isolates from Germany and Krasnodar. The NA sequences from the Czech Republic have G743A, as do the isolates from Krasnodar and Germany. The first reported clade 2.2.3 sequences with G743A are from the February, 2007 outbreak in Kuwait. These acquisitions were in isolates collected at the same time as distinct clade 2.2.3 isolates from Moscow, and clade 2.2.1 isolates from Egypt. The concurrent acquisitions of G743A in these distinct H5N1 clade 2.2 isolates raise serious questions about H5N1 via adaptive mutations.
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