H1N1 Greek and Russian D225G Sequences Identical



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	H1N1 Consulting Paradigm Shift Viral Evolution Intervention Monitoring Vaccine Screening Vaccine Development Expression Profiling Drug Discovery Custom Therapies Patents	Audio:Jan21 Feb2 Feb13 Feb18 twitter Live feed of underlying pandemic map data here Commentary H1N1 Greek and Russian D225G Sequences Identical Recombinomics Commentary 18:50 March 10, 2010 Recent sequences from the National Influenza Centre for northern Greece include 9 sequences from 2010, of which 3 had D225G. Three more November isolates had D225G, including A/Thessaloniki/2812/2009. Three of the isolates had D225G as the only recent change, but the other three has polymorphisms found in three different sub-clades. The above sequence was an exact match (see list here here here here) with A/Bryansk/IIV2971/2009, which had been collected 11 days earlier from a lung sample, suggesting the Russian sequence was from a fatal case. Clinical information from the Greek isolate was not included, but the samples were from a study of severe and fatal cases in Greece, suggesting the D225G positive samples were from such cases. The identity between the samples collected in Russia and Greece 11 days apart provides compelling evidence that the H1N1 is transmitting with D225G and is not due to spontaneous mutations, which is the WHO working hypothesis. Transmission is also supported by sequences from autopsy lung in Ukraine, where 27/37 samples had D225G, D225N, or both. The same association of these changes with fatal cases was seen in the Duke death cluster where 3 of 4 samples from the first three patients, who were on the same ward, had D225G or D225N. The three D225G cases in 2010 is the largest number reported to date from a single country this year and the nine cases from 2010 is also the largest number of sequences from a given country. D225G has been reported in a 2010 Russian isolate, but thus far there have been few 2010 sequences made public. However, the finding that D225G is in a Ukraine low reactor raises concerns that the frequency of D225G in 2010 cases will be markedly higher than 2009. Media Links Recombinomics Presentations Recombinomics Publications Recombinomics Paper at Nature Precedings
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