Widespread pH1N1 Tamiflu Resistance In South Korea



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H1N1 Consulting Paradigm Shift Viral Evolution Intervention Monitoring Vaccine Screening Vaccine Development Expression Profiling Drug Discovery Custom Therapies Patents	Audio:Feb18 Mar18 Mar31 Apr15 twitter Live feed of underlying pandemic map data here Commentary Widespread pH1N1 Tamiflu Resistance In South Korea Recombinomics Commentary 16:37 April 25, 2010 The CDC in South Korea has released 16 pH1N1 NA sequences at Genbank and 10 had H274Y. Although multiple samples appear to have been collected from two patients, more than half of the patients had H274Y, including the two infected in 2010. This increase of H274Y in recent cases is similar to data released by NIID in Japan. They recently released two more sequences, including one from 2010 and both had H274Y. Earlier, they had released recent sequences including seven from 2010 and six had H274Y. Thus, there have now been 10 sequences from Japan or Korea patients infected in 2010, and nine had H274Y, providing strong evidence of H274Y fixing on pH1N1. Moreover, one of the sequences from Korea had mixed signals with wild type, further supporting spread of pseudospecies contain H274Y at levels below detection. Another sequence from Korea has G158E in the HA, which has been linked to low reactor status, which has also been reported in Japan and the United States. Moreover, sequences from a D225G transmitting familial cluster in Italy had G158E in the index sequence, but not the infected family member, providing further support for psuedospecies. The fixing of H274Y in Korea and Japan is following data linked to the fixing of H274Y in seasonal H1N1. Initially, the polymorphism was concentrated in northern Europe, but it became fixed via genetic hitchhiking in the summer of 2008 and then became fixed worldwide in the following 2008/2009 season in the northern hemisphere. The linkage of H274Y with HA sequences like G158E and /or D225G, which have been linked to low reactor status raises concerns that recombination will lead to H274Y linkage to an emerging pH1N1 strain, which will be Tamiflu resistant and more virulent. Media Links Recombinomics Presentations Recombinomics Publications Recombinomics Paper at Nature Precedings

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