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Commentary
H7N9 Spread To
Fujian Province
Recombinomics
Commentary 13:00
April 26, 2013
Chinese Center for Disease Control at 11 o'clock on the April 26 review of test results for the H7N9 avian influenza virus nucleic acid positive.
The above translation describes the first confirmed H7N9 bird flu case in Fujian province. This case (65M) represents a significant geographic spread. This week cases were reported for the first time in Shandong and Jiangxi Provinces, which represented an incremental spread. Similarly, the detection of the case in Taiwan represented an infection that originated in Jiangsu, just north of Shanghai.
However, the confirmation of H7N0 represents a significant jump, and the upcoming May 1 travel will likely spread H7N9 throughout China and beyond.
Although the sequences from human cases are closely related to those found in birds in live markets, the human PB2 sequences contain mammalian adaptation changes (E627K or D701N) signaling human to human transmission.
The movement of such changes to Fujian Province raises serious pandemic concerns.
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