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Commentary
MERS Clonal Expansion In Jeddah and Mecca
Recombinomics Commentary 16:00
May 8, 2014
The first three sequences had nine polymorphisms that were in all three Jeddah patients, but not in any published sequence. Subsequently, sequences from camels in Taif were described in an mBio paper and four were closely related (see list below). However, none of the camel sequences had all 8 polymorphisms. Two camel sequences (378 and 505) had 5 of the 8 polymorphisms and none of the camel sequences had A23953G, which encoded Q833R in the spike protein, or T28778A, which encoded L6Q in ORF8b.
The three newly released human sequences had all none of the polymorphisms. Thus, all six humans sequences from three hospitals in Jeddah as well as a hospital in Mecca uniquely matched each other signaling clonal expansion in western Saudi Arabia.
The emergence of this novel sub-clade and spread throughout Jeddah and Mecca raises serious pandemic concerns.
8 Polymorphisms Define Novel Jeddah Sub-clade
Nucleotide Protein Camel
C2490T 378
C5658T P1794S 378 505 503 363
C9659T 378 505 503 363
T12257C 378 505
T16174C 505 503
C23804T 378 505 503
A23953G Q833R
T28778A L6Q
T28880C L40P 378 505
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