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Commentary
H7 G228S Raises
H7N9 Pandemic Concerns
Recombinomics
Commentary 23:45
May 22, 2013
The above comments from a New England Journal of Medicine paper, Live-Animal Markets and Influenza A (H7N9) Virus Infection, cite the second key receptor binding domain change in H7, G228S in A/Nanjing/1/2013 and A/environment/Nanjing/2913/2013.
The NEJM quote is INCORRECT. The above links were activated by Genbank today and G228S is NOT present in either sequence.
The combination of Q226L and G228S was present in the 1957 H2N2 pandemic and well as the 1968 H3N2 pandemic, and both changes were introduced into two of the three H5N1 bird flu transmission experiments (the other experment used N224K and Q226L and the recently released sequence, A/Shanghai/patient1/2013, has N224I and Q226L).
The appearance of these changes in H7N9 may be facilitated by the H9N2 internal genes.
However, the presence of Q226L and G228S in the above case (45F) raises serious pandemic concerns.
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