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Commentary

Asymptomatic H5N1 Chickens in Hong Kong
Recombinomics Commentary 17:44
June 9, 2008

The "trouble" of the security Road Market, 9 stall chicken stalls in the three files found that the H5N1 virus, the stall owners did not notice before AFCD had appeared dead chickens. However, the neighbouring "no problem chicken" for the chicken stalls Miss Lai said, in the past 1-2 weeks have been dead for three live chickens, more than ever before. FEHD Zuozao the chicken stalls in the market stalls blockade 9, 14:30, the staff wearing protective clothing markets, the destruction of 2,700 poultry.

The above translation indicates there were no usual poultry deaths in stalls that tested positive for H5N1.  The detection of H5N1 in 5 of 20 samples in these stalls suggest the H5N1 infected chickens were asymptomatic.

Asymptomatic H5N1 infections are more common in waterfowl, raising concerns that either the H5N1 has changed, or the chickens have protective immunity that keeps birds asymptomatic, but allows for viral shedding.

Asymptomatic chickens have been reported previously in Vietnam, but that H5N1 was clade 1.  The common H5N1 infection in southern China is clade 2.3 (Fujian strain), which has also been detected in wild birds in Hong Kong for the past several years.

Although the sequences from wild birds generated in 2007 and 2008 have been withheld, one of the 2007 isolates has been selected as a clade 2.3.2 vaccine target, and the HA phylogenetic tree containing that isolates indicates it is closely related to the H5N1 sequences from Japan and Primorsky, which are closely related to the H5N1 in South Korea.

Although H5N1 surveillance has be increased in Hong Kong following the human cases in 1997 and multiple poultry outbreaks in subsequent years, there have been no H5N1 reports in poultry in the last five years.

The current outbreak raises concerns of a significant H5N1 reservoir in southern China, which may be related to the wild bird outbreaks further north along the east edge of Asia, which lies in the East Asian flyway.

The outbreak in China raises additional concerns of a global expansion for the Fujian strain of H5N1.

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