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Commentary
2013 Grant
County Indiana H3N2v Matches 2012 Cases
Recombinomics
Commentary 18:15
June 28, 2013
The above comments are from the CDC week 25 Fluview, which has additional information on the four H3N2v confirmed attendees of the Indiana Grant County Fair (see map). Although the sequence described above has not been released, the comment of 99% similarity with the 2012 cases suggests that the 2013 sequences have the same lineages for each of the 8 gene segments that were present in the vast majority of human H3N2v sequences.
These sequences were dominant in the recent Indian swine sequences released by the USDA and suggest the above sequence will be closely related to those sequences ((A/swine/Indiana/A01260252/2013, A/swine/Indiana/A01260254/2013, A/swine/Indiana/A01260261/2013, A/swine/Indiana/A01260276/2013, A/swine/Indiana/A01260280/2013, A/swine/Indiana/A01260284/2013). Similar sequences were found in 2013 isolates from Ohio swine, raising concerns that Indiana and Ohio will again have the most confirmed cases in 2013, which were 138 and 107, respectively, in 2012.
However, the dominance of this sub-clade in the 2013 H3N2v swine sequences released by the USDA, and the early occurrence of the Indiana, outbreak raises concerns that the 2013 human H3N2v cases will exceed 2012.
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