Recombination and G158E Duplication In H1N1 Iowa Swine



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H1N1 Consulting Paradigm Shift Viral Evolution Intervention Monitoring Vaccine Screening Vaccine Development Expression Profiling Drug Discovery Custom Therapies Patents	Audio:Mar31 Apr15 May20 Jun17 twitter Live feed of underlying pandemic map data here Commentary Recombination and G158E Duplication In H1N1 Iowa Swine Recombinomics Commentary 16:50 July 6, 2010 The recently released HA sequence from A/swine/Iowa/03032/2010 has a six BP duplication which includes G158E. Thus instead of the wild type sequence for positions 156-159 changing from KKGN to KKEN, as found in many low reactors, the Iowa swine sequence has KKEKEN, which almost certainly leads to significant immunological escape. The isolate was collected a month ago and the genetic background is similar to humans infected by swine H1N1 in 2007 in Ohio. However, the sequence has also acquired pH1N1 sequences that are found in almost all pH1N1 isolates. Moreover, most of these polymorphisms are non-synonymous and at least one polymorphism traces back to 1918. These acquisitions raise concerns that this virus could quickly gain efficient and sustained transmission in humans, leading to a co-circulating H1N1 pandemic. More intense screening of swine in the United States would be useful. Media Links Recombinomics Presentations Recombinomics Publications Recombinomics Paper at Nature Precedings