Recombinomics Concurrent Acquisitions at Nature Precedings
Recombinomics Commentary
July 16, 2007
Recombinomics has begun submitting papers to Nature's new site, Nature Precedings. The site allows papers to be viewed by the scientific community, if accepted by Nature's professional curators.
The site also allows for comments and voting (both require log in after registration, which is free). Thus, the papers are "open access". No Nature subscription is required to download the papers (or vote or comment).
Recombinomics first paper, "Swine Influenza A Evolution via Recombination - Genetic Drift Reservoir" is available at Nature (where it can be downloaded). It is the most popular paper at the site.
Recombinomics second paper, "H5N1 Concurrent Acquisition of a Single Nucleotide Polymorphism in Diverse Influenza Clade 2.2 Sub-clades" is now also available at the site.
These papers will significantly impact the two basic tenets of influenza genetics, drift via "random mutation" and shift via reassortment.
The latest paper describes the concurrent detection of NA G743A in three countries, Russia, Egypt, and Ghana. This polymorphism was appended onto six different genetic backgrounds, which is difficult to explain by “random mutations”.
Recombination involving acquisition of H5N1 sequences from migratory birds, and appending the polymorphisms onto resident H5N1 genetic backgrounds straightforwardly explains the data. The polymorphism tracing used to identify this change, as well as others, including the changes in or near the HA receptor binding domain, V223I and M230I, can be used to develop vaccine targets in advance of the detection of the polymorphisms on new genetic backgrounds.
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Recombinomics Presentations
Recombinomics Publications
Recombinomics' Paper at Nature Precedings