Paradigm Shift Intervention Monitoring
twitter
Commentary
H3N2v
Cluster At Indiana County Fair
Recombinomics
Commentary 22:30
July 26, 2012
On July 21, partial genome sequencing at CDC confirmed H3N2v virus with the H1N1pdm09 virus M gene; the viruses detected in the four specimens are similar to 12 viruses detected in 2011 and one detected earlier this year
The above comments from tomorrow’s MMWR describe the largest cluster of confirmed H3N2v cited to date. Moreover, the detection of H3N2v in contact swine also represents the first reported linkage for H3N2v between an human H3N2v cluster and contact swine.
Recently released sequences by Iowa State University included for June isolates from Ohio (A/swine/Ohio/1/2012, A/swine/Ohio/6/2012, A/swine/Ohio/7/2012, A/swine/Ohio/9/2012) as well as May isolates from Iowa (A/swine/Iowa/A01203503/2012) and Indiana (A/swine/Indiana/A01203521/2012 and A/swine/Indiana/A01203522/2012), which matched the initial human cases from 2011).
However, an additional May isolate from Indiana (A/swine/Indiana/A01203509/2012) match the more recent human cases from West Virginia (A/West Virginia/06/2011 and A/West Virginia/07/2011) and Utah (A/Utah/10/2012), which had an N2 from a swine H3N2 lineage (while the earlier cases had an N2 from a H1N2 lineage).
Thus, it is unclear if the recent cases have the H1N2 or H3N2 N2 gene. Similarly, it is unclear if the county fair was in Cass or LaPorte, both of which were held from July 8-14.
Release of the human and associated swine sequences would be useful.
Recombinomics
Presentations
Recombinomics
Publications
Recombinomics
Paper
at Nature Precedings