CDC Issues H3N2 Health Advisory



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H1N1 Consulting Paradigm Shift Viral Evolution Intervention Monitoring Vaccine Screening Vaccine Development Expression Profiling Drug Discovery Custom Therapies Patents	Audio:Apr15 May20 Jun17 Jul15 twitter Live feed of underlying pandemic map data here Commentary CDC Issues H3N2 Health Advisory Recombinomics Commentary 10:25 August 09, 2010 The CDC has issued a Health Advisory in connection with two summer outbreaks of H3N2 in Iowa. In association with the alert, the published a series of Perth-like H3N2 sequences at GISAID, including A/Iowa/07/2010 which was collected July 12, 2010. The CDC had published additional 2010 H3N2 sequences earlier, as had Mill Hill in the UK, the WHO regional center in Australia, and NIID in Japan. The 2010 sequences, as well as sequences from late 2009 formed a well defined sub-clade. 2010 isolates from the US were from New York, Rhode Island, Arkansas, California, Virginia, Connecticut, Iowa, Kansas, and Pennsylvanian (see lists here). The sequence from Kansas (A/Kansas/06/2010) had a large number of non-synonymous changes, including I230V (which was also in A/Pennsylvania/02/2010). As seen in earlier Perth-like sequences, the above sequences had D225N. In addition to 2010 sequences from the US, full 2010 HA sequences in the sub-clade were from Tanzania, Singapore, Hong Kong, Nicaragua, China, Kenya, Italy, and Bolivia. This large and widespread sub-clade is likely to dominate H3N2 sequences in the upcoming months. Media Links Recombinomics Presentations Recombinomics Publications Recombinomics Paper at Nature Precedings

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