Paradigm Shift Intervention Monitoring
twitter
Live feed of underlying pandemic map data here
Commentary
Pandemic
H1N1 RBD Change In Recent 2010 Isolates
Recombinomics
Commentary 04:16
September 16, 2010
Subsequently the US CDC released sequences (at GISAID) from a series of 2010 samples, including three from India. Two of those samples (A/India/5107/2010 and A/India/8910/2010) also had S188T. Most recently the WHO collaborative center in Australia released a large series of recent HA sequences (also at GISAID), largely from Australia and New Zealand. One sample from Australia (A/VICTORIA/512/2010) and one from New Zealand (A/CHRISTCHURCH/15/2010) had S188T.
S188T is adjacent to receptor binding domain (RBD) position 190. When Tamiflu resistance emerged in seasonal H1N1, the fixing was linked to RBD change A193T, which was followed by changes at flanking positions (187, 189, 196) which was likely linked to immunological escape. Similarly the fixing of adamantine resistance in H3N2 was associated with a change at position 193 (S193F) and 225 (D225N). Pseudo-species at position 225 have been seen in pandemic H1N1 (D225E, D225N, D225G), with D225G most associated with fatal cases, so additional RBD associated changes are a concern.
The S188T change seen in recent 2010 isolates may signal changes linked to immunological escape. The linkage to swine and subsequent spread to humans in four countries raises concerns that the spread will increase in the upcoming flu season in the northern hemisphere.
Media Links
Recombinomics
Presentations
Recombinomics
Publications
Recombinomics
Paper
at Nature Precedings