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Commentary
Swine H3N2v
Matches With LaPorte and Butler Cases
Recombinomics
Commentary 16:15
September 19, 2012
Thus, the sequence data strongly supports interspecies transmissions at both county fairs.
However, these sequences don’t address the direction of the transmission. Prior to the fairs, only 2 of 31 swine matches with human 2011 and 2012 cases are from the sub-clade found in all 2012 human H3N2v cases. Moreover, none of the 57 public sequences from July and August 2012 cases are from the sub-clade found in the first 10 human cases in 2011. This novel sub-clade was first detected at the West Virginia day care center in late 2011 (A/West Virginia/06/2011 and A/West Virginia/07/2011), as well as the first 2012 H3N2 case, A/Utah/10/2012.
These distribution raise concerns that this novel sub-clade is widespread in humans (July / August cases were identified across the United States, from Hawaii to Maryland) and agricultural fairs create interactions leading to frequent human to swine transmission.
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