Paradigm Shift Intervention Monitoring
twitter
Commentary
Egypt MERS Recombinant Raises Surveillance
Concerns
Recombinomics Commentary
22:00
September 19, 2013
However, the other four sequences had clear evidence of evolution via homologous recombination. Two of the sequences (Bisha_1_2012 and Riyadh_1_2012) were virtually identical to each other (differed a 1 position) and had polymorphisms shared with England1 / UAE in the 5’ end and Al Hasa polymorphisms in the 3’ end. A more complex pattern was seen in Hafr-Al-Batin_1_2013, which had clusters of polymorphism from four different parents. The fourth sequence, Riyadh_3_2013, also has clear evidence of recombination with a cluster s of polymorphisms including four (T2456A, C3320T, T4847C, and T6332C) shared with EMC_12 / Jordan-N3 , which are downstream from the four Jordan-N3 / EMC-12 polymorphisms (A542G, T623C, T1514C, C1883A) found in Hafr-Al-Batin.
Riyadh_3_2013 also has a cluster of 7 polymorphisms found in England1 / UAE (C11492T, A11534G, G19075A, C20848A, C22790T, T24299C, G24515C) with the first five of these polymorphisms also present in Riyadh_1 / Bisha_1.
Riyadh_3_2013 was from a sample collected on February 5, 2013, which corresponds to a patient (61F) who developed symptoms while traveling in Egypt, suggesting the sequences represents unreported MERS circulating in Egypt, which is supported by antibodies found in camels raised in Egypt for slaughter.
The Riyahd_3 sequence highlights the need for more aggressive MERS surveillance in countries adjacent to KSA.
Recombinomics
Presentations
Recombinomics
Publications
Recombinomics
Paper
at Nature Precedings