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Three More H5N1 Cases Admitted In Jakarta
Recombinomics Commentary
September 21, 2005
DW was recorded as the citizen Cijantung, Jakarta East. He was diagnosed experienced the upper respiratory tract infection (ISPA). However the team of the doctor suspected DW of also being infected by the virus of birds flu.
"Was based on the report, a last week, 19 chickens and 5 doves belonging to his parents died suddenly," said Deputy Director RSPI Sulianti Saroso, Dr Sardikin Giriputro.
The machine translation above described DW (17F) who was admitted to Saroso today, along with JM (9F) and WED (18F).
WED transferred from RS Islam. Her parents maintained two pigeons but she did not have direct contact.
As noted above DW's parents had poultry that died suddenly.
The third patient, JM, had visited the Ragunan Zoo, where most randomly tested birds were H5N1 positive. Three or four zoo workers also developed H5N1 symptoms and two are also at the hospital.
In addition to the three patients who were admitted today, two other patients (Yesica Triana, YT, and Riska Ardian, RA) died today. RA had also transferred from RS Islam and YT was denied admission because her H5N1 test was pending and the three available respirators were in use by other bird flu patients.. All had bird flu symptoms.
The growing clusters, as well as the sudden burst of patients, signal a change in the ability of H5N1 to infect humans. Sequence data from the July family cluster as well as the first confirmed case in the current cluster did not indicate that there was reassortment between avian and human genes. The H5N1 from the patients was similar to the H5N1 from Indonesian poultry.
H5N1 from Asia was first isolated in Asia in 1996. The first reported human cases were in 1997 and although there has been reassortment between avian genes, an H5N1 isolate with one or more human genes has not been reported. Instead, H5N1 has evolved via acquisition of polymorphisms. In Vietnam and Thailand, most of the polymorphisms have been from mammalian isolates.
The sudden jump in H5N1 cases this week is cause for concern. The case fatality rate for H5N1 confirmed and suspect acute cases in Indonesia remains at 100%.
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