Worldwide Spread of H1N1 S188T Via Clonal Expansion



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H1N1 Consulting Paradigm Shift Viral Evolution Intervention Monitoring Vaccine Screening Vaccine Development Expression Profiling Drug Discovery Custom Therapies Patents	Audio:Jun17 Jul15 Aug19 Sep16 twitter Live feed of underlying pandemic map data here Commentary Worldwide Spread of H1N1 S188T Via Clonal Expansion Recombinomics Commentary 18:17 October 15, 2010 Mill Hill has released HA and NA sequences (at GISAID) from recent 2010 isolates in Africa. Two HA sequences from Ghana (A/Ghana/FS-10-4241/2010 and A/Ghana/FS-10-4259/2010) and two from South Africa (A/Johannesburg/114/2010 and A/Johannesburg/119/2010) had S188T. This polymorphism was initially seen in swine pandemic H1N1 in Thailand from early 2010. That sequence was followed by two human sequences from Thailand. The human sequences from Thailand were partial sequences, but two full HA sequences from India had G605T (S188T) as well as T106C and G1403A (S454N). This same combination was found in sequences in Australia, New Zealand, and the United States (see list here and here). The same combination of polymorphisms was present in all four sequences from Africa. The detection of all three polymorphisms indicates S188T is spreading in human populations via clonal expansion. The finding of two sequences in countries where the number of recent HA sequences is limited suggests that S188T may be in a high percentage of recent H1N1 infections in Thailand, India, Ghana, and South Africa. These high frequencies may signal linkage of S188T to immunological escape and the emergence of a dominant sub-clade, as was seen during the fixing of H274Y in seasonal H1N1. The rapid spread of S188T remains a cause for concern. Media Links Recombinomics Presentations Recombinomics Publications Recombinomics Paper at Nature Precedings

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