Commentary
Dominant
Tamiflu Resistant H1N1 Sub-clade in Europe
Recombinomics Commentary
12:56
October 29, 2008
More recently, isolates in South Africa and Kenya, had a series of changes in this subclade located near the receptor binding domain at position 190 (H3 numbering), raising concerns that the current vaccine, which targets Brisbane/59 may not be as effective this season.
The sub-clade which dominated last season in the northern hemisphere is evolving, and the evolved versions are associated with an increase in H274Y frequency to 100% in South Africa (225/225 sequenced isolates had H274Y).
The dominance of this sub-clade appears to be extending to the current flu season in the northern hemisphere, where the first H1N1 isolates in Canada and the UK have H274Y.
Dominant H274Y Clade 2B sub-clade
Norway/1736/2007
Canaries/RR-2915/2007
Denmark/27/2007
Kiev/313/2008
Berlin/47/2008
Geneva/9296/2008
Lyon/1337/07
Parma/34/08
Athens/41/2008
Austria/406109/2008
Bucurest/229/2008
Belgium/G257/08
Slovenia/123/2008
Lisbon/3/2008
Other H274Y Clade 2B sub-clade
England/684/2007
Scotland/5/2007
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