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Commentary
H1N1
Evolution In Thailand Raises Pandemic Concerns
Recombinomics
Commentary 17:57
November 10, 2010
These earlier sequences have an H1 related to North American swine, and an N1 related to European swine. This combination is also found in the 2009 pandemic H1N1, which spread worldwide in 2009.
In addition to the reassortment, one of the isolates has a recombinant MP. The first 1/3 of the MP gene is related to the H1N1 Thai swine which contributed N1. However, the remainder of the MP gene is pH1N1.
In addition to reassortment and recombination involving a long segment of swine H1N1, the N1 sequences have genetic drift from acquisitions from avian sequences, including H5N1, as well as pH1N1 polymorphisms. The MP gene also has aquired avian sequences.
The high degree of diversity in 2010 swine H1N1 sequences raise concerns that the variations will lead to more dangerous variants which will again jump to humans while avoiding immunity directed against pH1N1.
The dramatic diversity in Thailand demands close surveillance and analysis.
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