H1N1 D225G in Russia Raises Pandemic Concerns



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H1N1 Consulting Paradigm Shift Viral Evolution Intervention Monitoring Vaccine Screening Vaccine Development Expression Profiling Drug Discovery Custom Therapies Patents	Audio: Nov9 Nov16 Nov 18 Nov19 twitter Live feed of underlying pandemic map data here Commentary H1N1 D225G in Russia Raises Pandemic Concerns Recombinomics Commentary 17:05 November 20, 2009 A new sequence from Russia, A/Vladivostok/1/2009, was just placed on deposit at Genbank. The HA sequence has D225G which has come into focus because it was in all four fatal cases from Ukraine. This polymorphism has also been in recently released sequences from Australia and China. Although the date of collection for the Russian sequence was not included its recent appearance adds to concern that D225G is becoming more common, as death rates throughout the northern hemisphere increase. Moreover, today Norway is holding a news conference on a "mutation" found in dead or dying patients, which may also be D225G. The detection of this change may be more frequent in necropsy lung tissues. Release of sequences from such samples would be useful. The D225G has been found on multiple genetic backgrounds, indicating it is spreading via recombination. Media Links Recombinomics Presentations Recombinomics Publications Recombinomics Paper at Nature Precedings