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Commentary
H5N8 Spread In Europe Mimics H5N1 In 2005
Recombinomics Commentary
November 21, 2014 17:30
The approximately 10,000 animals at the first company in Kamperveen where bird flu was found "culled as soon as possible" by the Dutch Food and Consumer Authority (NVWA). In the other two poultry farms, which are within a radius of 1 kilometer from the first farm, the regulator found "clinical symptoms" that fit bird flu. For that reason, companies are still culled today.
FIVE CASES
This morning it became clear that the animals Kamperveen infected with an H5 strain of bird flu
The above comments describe the likely infection by H5N8 on three farms in Kamperveen (see map). H5 has been confirmed in one, and the other two are within 1 kilometer, suggesting symptomatic birds on all three farms are infected with H5, which is almost certainly H5N8.
The Netherlands has file on OIE report confirming H5N8 in an earlier outbreak, which has also been done by Germany and England. Moreover, agencies within all three countries have deposited sequences at GISAID (A/turkey/Germany-MV/R2472/2014, A/Ch/Netherlands/14015526, A/duck/England/36254/14) which confirm the close genetic relationship between all three outbreaks with earlier sequences from Korea, Japan, and China.
This close genetic relationships suggest infections are linked to long range migratory birds, which is further supported by recent OIE reports from Japan confirmed H5N8 in droppings from Tundra swans as well as additional wild birds.
The above comments strongly suggest H5N8 infections are on 5 farms in the Netherlands in addition to the farms in Germany and England.
The detection in multiple European countries, as well as Japan, of an H5 sub-clade previously limited to Asia has striking parallels with the detection of the Qinghai strain (clade 2.2) in the fall of 2005. In early 2006 H5N1 was reported in a large number of countries in Europe, the Middle East, Africa, and south Asia involving wild birds, poultry, and mammals including humans.
Although the public H5N8 sequences lack well characterized markers linked to mammalian infections, this version of H5N8 may rapidly spread in poultry in countries matching the Qinghai outbreak in 2005/2006.
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