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Commentary
CDC Again Cites
Swine Exposure In Request for trH3N2 Samples
Recombinomics Commentary 18:25
November 24, 2011
Although swine exposure was not
associated with the three cases described in this report, because most
previous cases of human infection with S-OtrH3N2 viruses have occurred
in patients who reported swine exposure before illness onset,
clinicians should consider swine-origin influenza A virus infection in
the differential diagnosis of patients with febrile respiratory illness
who have had contact with swine. It is anticipated that commercially
available diagnostic tests, including point-of-care rapid tests, will
detect infection with the S-OtrH3N2 virus; however, these tests will
not differentiate S-OtrH3N2 from seasonal influenza A viruses.
Clinicians who suspect swine influenza virus infections in humans
should treat with oseltamivir when indicated (7), obtain a
nasopharyngeal swab from the patient, place the swab in viral transport
medium, and contact their state or local health department to
facilitate transport and timely diagnosis at a state public health
laboratory, using the CDC RT-PCR assay cleared by the Food and Drug
Administration. CDC requests that state public health laboratories send
all suspected novel influenza A specimens, such as these S-OtrH3N2
viruses, to the CDC Influenza Division's Virus Surveillance and
Diagnostics Branch Laboratory.
The above request for samples is from the
latest CDC MMWR on trH3N2 transmission. Like the first
report, which described the first two cases with the novel trH3N2
constellation with an M gene from H1N1pdm09, this report confuses the
need for samples from children, with the CDC’s need to maintain its charade
on the linkage between trH3N2 infections and swine “exposure”.
The above comments acknowledge the technical difficulties in
identifying trH3N2, which has led to a heavy bias on testing, which
created the illusion of an epidemiological link between trH3N2
infections and swine exposure, which in fact is a link between trH3N2
testing and swine exposure.
The CDC should end its charade (including using "S-OtrH3N2" for a novel
trH3N2 which has nothing to do with swine) and simply test (including
sequence) the large number of influenza A positve samples from
patients under 10 years of age, and issue a request for such samples
with no swine exposure.
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