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Commentary
Minnesota
trH3N2 Matches Wisconsin and Pennsylvania
Recombinomics
Commentary 00:55
December 21, 2010
The above comments from the Global Alert and Response flu update of December 17,2010, confirm the prediction that the sequences from the recently announce trH3N2 case in Minnesota will be closely related to the isolates from Wisconsin (September 6 infection) and Pennsylvania (October 24 infection). The CDC recently released these sequences as well as the two prior trH3N2 cases, which were related to the first trH3N2 case in Kansas (August 2009).
Four of the five prior isolates were closely related and had PB1 E618D, as well as additional polymorphisms that were found in all four human isolates but no recent swine isolates. This relationship raised concerns that the trH3N2 virus were circulating in a human population, which would lead to more isolates in the same lineage. The above comments confirm that relationship, which also includes a May isolate from Minnesota (also closely related to the Wisconsin and Pennsylvania isolates).
Since the second Minnesota isolate was from a November infection, it was assumed that the sequence would be close to the two preceding sequences, but would have a limited number of differences.
The above confirmation supports an emerging H3N2 swine pandemic and dictates more aggressive surveillance of human cases in the region.
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