Commentary
Uvs
Lake
H5N1 Migrates to Chany Lake in Siberia
Recombinomics Commentary
02:22
December 22, 2008
This strain was subsequently detected in South Korea and Japan at the end of 2006 / beginning of 2007 and the Chany Lake sequence is most closely related to a subset from South Korea collected from a fecal sample near a poultry outbreak as well as from poultry.
The Uvs Lake strain subsequently appeared in Kuwait in early 2007. In Kuwait, the Uvs Lake strain, like isolates in Russia, Egypt, Ghana, and Nigeria acquired G743A on NA. The Uvs Lake strain was subsequently found in wild birds in the Czech Republic, Germany, and France during the summer of 2007. In the fall and winter Uvs Lake spread throughout Europe and all public sequences have G743A.
In addition, sequences from a 2005 isolate from Kazakhstan were released, and these sequences are also related to the Uvs Lake sequences, suggesting the Kazakhstan sequences, from June, 2005 gave rise to the Uvs Lake sequences from the outbreak a year later.
These wild bird sequences help trace the movement of H5N1, and predict the emergence of new sub-clades, as well as the evolution of existing sub-clades.
The current outbreaks in India and Bangladesh are also likely related to these sequences. All prior outbreaks in India, Bangladesh, Afghanistan, and Pakistan have been clade 2.2.3, although the public sequences from Pakistan, Afghanistan, and India in 2006 are not the Uvs Lake strain of clade 2.2.3.
The recently release 2006 sequences from Russia or 2005 sequences from Kazakhstan help trace (see 2005 map) the evolution of H5N1, which is important for vaccine development. Therefore release of sequences soon after isolation is preferable to release 2-3 years after the fact.
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