Paradigm Shift Intervention Monitoring
twitter
Commentary
Minnesota
trH3N2 Is A Ressortant With PB1 E618D
Recombinomics
Commentary 03:05
December 23, 2010
The HA sequence is most closely related to WI/12 and the PB1 has E618D, which is in virtually all pandemic H1N1 sequences and in five of the six trH3N2 sequences. These five PB1 sequence are very closely related to each other and easily distinguished from other triple reassortants, signaling evolution within the human population. Other gene segments show similar phylogenetic profiles which produce branches with only a subset of the human trH3N2 sequences.
However, MN/11 is a reassortant, and the NA sequence is distinct from the 5 prior human trH3N2 sequences as well as swine trH3N2 sequences.
The latest trH3N2 sequence provides additional data supporting an emerging swine H3N2 pandemic. There have now been four trH3N2 cases in 2010 and all are more closely related to each other than swine sequences. The four this year brings the total number of human trH3N2 cases in the US to six, all reported after the start of the 2009 H1N1 pandemic. Moreover, there have been no reports of human trH1N1 or trH1N2 during this time suggesting the pH1N1 has crowded out trH1 infections in humans,
The increasing frequency of trH3N2 cases (three in three months) and the genetic similarity between these sequences support an emerging trH3N2 swine pandemic.
Media link
Recombinomics
Presentations
Recombinomics
Publications
Recombinomics
Paper
at Nature Precedings