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Paradigm
Shift
Viral
Evolution
Intervention
Monitoring
Vaccine
Screening
Vaccine
Development
Expression
Profiling
Drug
Discovery
Custom
Therapies
Patents
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Paradigm
Shift
The
analysis of recombination will generate a paradigm shift in the way
molecular evolution is viewed. Influenza
is an ideal system for studying molecular evolution. Viruses are
generally thought to evolve via shifting and drifting.
Shifting occurs when viruses swap genes and drifting was
thought to be due to a steady accumulation of mutations.
However,
rapidly
evolving viruses simply recycle old mutations via recombination. This method is much more efficient and follows
specific rules. These rules appear to be
followed by all viruses, including influenza, HIV, SARS, WNV. These rules allow vaccines to be prepared
before viruses emerge. These observations
will produce a paradigm shift in the study of molecular evolution via
recombination, which will provide solutions for unmet health needs
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